Antifungal agent for the treatment of skin disease caused by trichophyton, eczema or various fungi, and also for activating the recovery of the skin and burns

ABSTRACT

An antifungal agent for the treatment of skin disease such as athlete&#39;s foot, ringworm and tinea caused by dermatophytes, eczema, tinea or various fungi, which comprises a 100 weight % of detergent solution including 0.01-40 weight % of sodium hypochlorite, 0.01-30 weight % of sodium sulfite, 0.01-40 weight % of sodium nitrite, 0.01-40 weight % of sodium chlorate, 0.01-40 weight % of potassium chlorate, 0.001-35 weight % of hydrogen peroxide, 0.01-40 weight % of ozone water, 0.01-40 weight % of sodium nitrite, 0.01-40 weight % of potassium nitrite, 0.001-1 weight % of nonionic surface active agent and 1-90 weight % of water. 
     It is characterized in that trichophyton, eczema or various fungi in the dermis or deep layer are allured by oxygen contained in the antifungal agent to or near the surface of the skin for easy sterilization by oxidation, reduction, bleaching and fungicidal activity. 
     A ligand agent is also efficacious for the treatment of a burn of the skin and of stiffness in the shoulder.

BACKGROUND OF INVENTION

1. Field of the Invention

This invention relates to an antifungal agent for the treatment of skindisease (infecticosa eczematoides or Engmaris disease) caused bytrichophyton, eczema or various fungi, and also for activating therecovery of the skin disease and burns.

More particularly, this invention relates to an antifungal agent for thetreatment of skin disease such as athelete's foot, ringworm and tinea byoxidation, reduction, bleaching and fungicidal activity of theantifungal agent, which is characterized in that trichophytons orvarious fungi in a deep layer of the skin are allured by oxygencontained in the antifungal agent to or near the surface of the skin foreasy sterilization, and also for activating the early recovery of theskin diseases and burns.

2. Description of the Prior Art

In case trichophyton causing athlete's foot or ringworm are in theepidermis of the skin, it is comparatively easy to sterilize them. Whenthey are in a deep layer such as keratin or dermis of the skin, completesterilization of trichophytons cannot be expected, thus leaving the skindisease beyond medical treatment.

Some antifungal agents containing econazole nitrate, phydone derivativeor miconazole nitrate for the remedy of athelete's foot and ringwormhave been proposed, in which keratin or the epidermis and the dermis ofthe skin are corroded by another medicine.

Since the healthy skin is also corroded, the early recovery of the skinaffected with dermatotophytoses, eczema or various fungi cannot beexpected.

Another conventional antifungal agent containing fluoride for the remedyof athelete's foot or ringworm has also been proposed, but fluoride notonly sterilizes trichophyton, but also corrodes the healthy epidermis,dermis and deep skin and even the bone as well.

SUMMARY OF THE INVENTION

A principal object of this invention is to provide an antifungal agentfor the treatment of skin disease such as athlete's foot, ringworm andtinea by oxidation, reduction, bleaching and fungicidal activity of theantifungal agent, which is characterized in that trichophyton or variousfungi in a deep layer of the skin are allured by oxygen contained in theantifungal agent to or near the surface of the skin for easy and earlysterilization.

Another object of this invention is to provide an antifungal agent foractivating the recovery of skin disease (infecticosa eczematoides orEngmaris disease) caused by trichophyton, eczema or various fungi whichis characterized in that oxygen contained in the antifungal agent playsin important role in the recovery of the affected skin or a burn of theskin.

Another object of this invention is to provide an antifungal agent forthe treatment of skin diseases such as athlete's foot, ringworm andtinea in a safe and economic manner.

A further object of this invention is to provide a liquid agent (orlotion) for the treatment of a burn of the skin.

Still another object of this invention is to provide a liquid agent (orlotion) for the treatment of stiffness in the shoulders.

ESSENTIAL FEATURE OF THE INVENTION

An antifungal solution for the treatment of the skin diseases such asathlete's foot, ringworm and tinea of this invention comprises sodiumhypochlorite, sodium sulfite, sodium nitrite, sodium chlorate, potassiumchlorate, hydrogen peroxide, ozone water, sodium nitrate, potassiumnitrate, nonionic surface active agent and water, and it ischaracterized in that trichophyton or various fungi in a deep layer ofthe skin are allured by oxygen contained in the antifungal agent to ornear the surface of the skin for easy sterilization and also foractivating the early recovery of the skin affected with dermatophytes,eczema or various fungi by oxidation, reduction, bleaching andfungicidal activity of the antifungal solution, and that the skinaffected with the dermatophytes, eczema or various fungi can berecovered quite easily and early.

EXAMPLES Example 1

A detergent solution of an antifungal agent for the treatment of skindiseases caused by trichophyton and eczema of this invention comprises a100 weight % solution including 0.01-40 weight % of sodium hypochlorite,0.01-30 weight % of sodium sulfite, 0.01-40 weight % of sodium nitrite,0.01-40 weight % of sodium chlorate, 0.01-40 weight % of potassiumchlorate, 0.001-35 weight % of hydrogen peroxide, 0.01-40 weight % ofozone water, 0.01-40 weight % of sodium nitrate, 0.01-40 weight % ofpotassium nitrate, 0.001-1 weight % of nonionic surface active agent and1-90 weight % water.

Example 2

A detergent solution of the antifungal agent for the treatment of skindiseases caused by trichiphyton and eczema described in Example 1 has pHvalue between 4-12.

Example 3

The detergent solution of the antifungal agent was adjusted to have thepH value of 12. The adjusted solution was applied once a day to theflaky, oozy and cracked skin on the sole of a foot of a 48 year old man.After three days of its application, the trichophyton was completelysterilized, taking away not only usual urtication of the athlete's foot,but also urtication felt when the body temperature of the patient rises.

At the same time, the skin affected with the athlete's foot recoveredquite earlier than the case treated with the conventional remedy forathlete's foot.

Example 4

The aforementioned solution was applied once a day to eczema on theinstep of a foot and on the back of a hand of a 55 year old woman,curing her of the diseases completely after about 3 days.

Example 5

The aforementioned solution was applied once a day to dermatophyte andeczema of a toenail of a 55 year old man, and cured him of the diseasescompletely after about 10 days.

Example 6

The aforementioned solution was applied once a day to dermatophyte onthe palm of a man 43 years old, and cured him of the disease completelyafter about 3 days.

Example 7

A cotton patch soaked with the aforementioned solution was applied atnight on both shoulders of a 57 year old man who had been suffering fromchronic stiffness in the shoulders, and facilitated the circulation ofthe blood to cure him of his chronic stiffness the next morning.

Example 8

A 54 year old woman burnt her left hand near the thumb for 3 square cmarea while frying "Tempura" (or Japanese deep-fat fried food). She hadapplied on the burn the aforementioned solution soaked in a cotton patchfor one week to cure her of the burn completely.

In accordance with the antifungal agent of this invention, it ischaracterized in that trichophytons or various other fungi in a deeplayer of the skin are allured by oxygen contained in the antifungalagent to or near the surface of the skin for easy and earlysterilization and also for activating the early recovery of the skinaffected with the aforementioned diseases and burns.

Although the foregoing invention has been described in some detail byway of illustration and example for purposes of clarity ofunderstanding, it will be be obvious that certain changes andmodifications may be practiced within the scope of the appended claims.

What is claimed is:
 1. An antifungal method for alluring fungi in a deeplayer of the skin to or near the surface of the skin for the treatmentof skin disease which comprises applying to the skin surface overlyingsaid fungi:a 100 weight % of detergent solution including 0.01-40 weight% of sodium hypochlorite, 0.01-30 weight % of sodium sulfite, 0.01-40weight % of sodium nitrite, 0.01-40 weight % of sodium chlorate, 0.01-40weight % of potassium chlorate, 0.001-35 weight % of hydrogen peroxide,0.01-40 weight % of ozone water, 0.01-40 weight % of sodium nitrate,0.01-40 weight % of potassium nitrate, 0.001-1 weight % of nonionicsurface active agent and 1-90 weight % of water.
 2. An antifungal methodas claimed in claim 1, which is applied as:an antifungal detergentsolution having a pH value between 4-12.
 3. An antifungal method asclaimed in claim 1 which comprises application of:a 100 weight % ofdetergent solution including 0.01-40 weight % of sodium hypochlorite. 4.An antifungal method as claimed in claim 1, which is applied for thetreatment of a burn on the skin of any portion of a human body.
 5. Anantifungal method as claimed in claim 1, which is applied for thetreatment of stiffness in the shoulders.
 6. An antifungal method asclaimed in claim 2 which comprises application of:a 100 weight % ofdetergent solution including 0.01-40 weight % of sodium hypochlorite. 7.An antifungal method as claimed in claim 2, which is applied for thetreatment of a burn on the skin of any portion of a human body.
 8. Anantifungal method as claimed in claim 2, which is applied for thetreatment of stiffness in the shoulders.
 9. An antifungal method asclaimed in claim 1, which is applied for the treatment of athlete'sfoot, ringworm or tinea caused by dermatophytes, eczema, tinea orvarious fungi.